ABSTRACT
Objective To understand the quality of life in patients with chronic obstructive pulmonary disease (COPD) ,and to analyze the influencing factors for their quality of life .Methods A total of 250 patients with COPD from 3 hospitals in Zhanjiang City were investigated by using the Chinese Scale Of World Health Organization (WHOQOL‐BREF) ,and the influencing factors for quality of their life were analysed ,as well .Results A total of 237 qualified questionnaires were reclaimed out of 250 questionnaires , and the response rate was 94 .80% .Scores of physiological aspect ,psychological aspect ,social relation ,environmental condition and comprehensive health self evaluation were (59 .57 ± 15 .73) ,(56 .99 ± 13 .01) ,(64 .28 ± 14 .82) ,(58 .70 ± 11 .53)and (74 .97 ± 12 .61) ,respectively .The scores of quality of life in the physiological aspect ,psychological aspect ,social relation and environmental condition of male patients with COPD were higher than those of the female ;the scores of quality of life in the social relation in pa‐tients with higher education level were higher than that in patients with lower education level ,the scores of quality of life in the physiological aspect ,psychological aspect ,social relation and environmental condition in patients with higher income level were high‐er than those in patients with lower income level ;the disease severity was higher ,the scores of quality of life in the physiological as‐pect ,psychological aspect ,social relation and environmental condition were lower ,all had statistically significant differences (P<0 .05) .Logistic regression analysis showed that sex ,monthly income level and disease severity were the influence factors of quality of life self evaluation in COPD patients .Conclusion The quality of life in patients with COPD might be influenced by sex ,income level ,level of education and disease severity .It is necessary to strengthen the health education ,pay attention to personalized care and improve the quality of life of patients with COPD .
ABSTRACT
[Objective]To explore the differentiation of bone marrow stromal cells(BMSCs) induced by OECs conditioned medium.[Method]The purified OECs were acquired by seleclive culture medium and cultivated in the polylysine coated plate.After 9～12 days culture, OECs conditioned medium was obtained by 2000 r/min configuration and then co-cultivated with purified BMSCs which were 3th generation.The differentiation of BMSCs were observed under inverted microscope and were identified by immumofluorescence method.[Result]The OECs conditioned medium had obviously effects on BMSCs' differentiation.BMSCs differentiation into neuron-like cells ratio was 55% and differentiation into astroctes cells ratio was 23%.[Conclusion]The conditioned medium which comes from OECs culture supernatant has obviously effects on BMSCs' differentiation into neuron-like cells.